Endocrine Abstracts

Endotoxemia induces behavioral changes, including a decrease of food intake. Several studies have demonstrated that ADX modifies central nervous system responsiveness to different paradigms. Control of energy homeostasis is regulated by interplay of peripheral signaling conveyed to the hypothalamus and brainstem that control appetite and meal size. We investigated the activity of oxytocin (OT) neurons in the paraventricular nucleus of the hypothalamus (PVN) and tyrosine hydrox...

Hypophagia and increased energy expenditure under inflammatory condition, such as observed after bacterial lipopolysaccharide (LPS) administration, are associated with activation of JAK2–STAT3 signaling in the CNS. High fat diet (HFD) is known to induce hypothalamic resistance to leptin signaling mediated by JAK2–STAT3 pathway. In this study we investigated the expression of p-STAT3 in the hypothalamus and brainstem of HFD treated animals under LPS (100 μg/kg) s...

CCK, secreted from duodenal cells in response to nutrients is involved in the satiety mechanisms, via activation of nucleus tractus solitarius (NTS). The arcuate (ARC) and paraventricular nuclei (PVN), which receives projections from NTS, integrate the circuitry that controls food intake. Corticotrophin releasing factor (CRF) participates in the energy homeostasis, decreasing food intake.To evaluate the effect of glucocorticoid on feeding and neuronal ac...